Year : 2016  |  Volume : 1  |  Issue : 4  |  Page : 138-144

Recent advancements in magnesium implants for orthopedic application and associated infections

Biocon Research Limited, Bangalore; Sahrdaya College of Engineering and Technology, India

Correspondence Address:
Jaslin P James
Biocon Research Limited, Bangalore; Sahrdaya College of Engineering and Technology
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2542-4157.194813

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In recent years extensive research on magnesium and its alloys as potential biodegradable implant materials have been carried out by various research groups around the world. Biodegradable magnesium alloys are more suitable for load-bearing implant applications than their polymeric counterparts because of their superior mechanical strength. Moreover, since their elastic properties resemble those of natural bone, they are considered ideal for hard tissue implants employed in fracture stabilization so that stress shielding is avoided and bone regeneration is enhanced. Also studies have shown that Mg alloy exhibit good biocompatibility with no systemic inflammatory reaction or affection of the cellular blood composition. One of the main advantages of biodegradable implants is the elimination of follow-up surgery to remove the implant after the tissue has healed sufficiently. Consequently, extensive studies have been carried out to develop Mg-based alloys with superior mechanical and corrosion performance. This review focuses on the following topics: (i) the design criteria of biodegradable materials; (ii) in vitro performances of currently developed magnesium alloys; (iii) improving properties of Mg based orthopedic implants using surface improvement techniques and other alloying methods; as well as (iv) implant infections and current methods.

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